I believe there exists, & I feel within me, an instinct for the truth, or knowledge or discovery, of something of the same nature as the instinct of virtue, & that our having such an instinct is reason enough for scientific researches without any practical results ever ensuing from them.

Ignorance more frequently begets confidence than does knowledge: it is those who know little, and not those who know much, who so positively assert that this or that problem will never be solved by science.

I do not know what I may appear to the world, but to myself I seem to have been only like a boy playing on the seashore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me.

Art is the queen of all sciences communicating knowledge to all the generations of the world.

Nor am I less persuaded, that you will agree with me in opinion, that there is nothing, which can better deserve your patronage, than the promotion of Science and Literature. Knowledge is in every Country the surest basis of public happiness. In one, in which the measures of Government receive their impression so immediately from the sense of the Community as in ours, it is proportionally essential.

We know more about the movement of celestial bodies than about the soil underfoot.